| 1. Round | 17/03/2018 | Rio Grande Valley FC | - | Saint Louis FC | 1:1 | ||||
| 1. Round | 01/04/2018 | Rio Grande Valley FC | - | Sacramento Republic | 2:2 | ||||
| 2. Round | 15/04/2018 | Seattle Sounders 2 | - | Rio Grande Valley FC | 3:2 | ||||
| 2. Round | 19/04/2018 | Portland Timbers 2 | - | Rio Grande Valley FC | 3:2 | ||||
| 2. Round | 26/04/2018 | Rio Grande Valley FC | - | Orange County SC | 2:0 | ||||
| 3. Round | 02/05/2018 | Rio Grande Valley FC | - | Reno 1868 FC | 0:0 | ||||
| 3. Round | 13/05/2018 | Rio Grande Valley FC | - | San Antonio FC | 0:0 | ||||
| 3. Round | 20/05/2018 | Rio Grande Valley FC | - | Swope Park Rangers | 0:0 | ||||
| 4. Round | 05/06/2018 | Real Monarchs SLC | - | Rio Grande Valley FC | 2:0 |
USA