| 1. Round | 27/08/2010 | Panathinaikos | - | Skoda Xanthi | 1:1 |  |
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| 2. Round | 12/09/2010 | Skoda Xanthi | - | Panionios GSS | 1:1 | ||||
| 3. Round | 18/09/2010 | Ergotelis | - | Skoda Xanthi | 1:0 | ||||
| 4. Round | 26/09/2010 | Skoda Xanthi | - | PAOK Saloniki | 1:0 | ||||
| 5. Round | 03/10/2010 | AEK Athen | - | Skoda Xanthi | 1:0 | |
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| 6. Round | 16/10/2010 | Skoda Xanthi | - | Olympiakos Piraeus | 0:3 | ||||
| 9. Round | 06/11/2010 | Skoda Xanthi | - | Iraklis Saloniki | 2:2 | ||||
| 12. Round | 28/11/2010 | Asteras Tripolis | - | Skoda Xanthi | 1:2 | ||||
| 13. Round | 05/12/2010 | Skoda Xanthi | - | Olympiakos Volou | 1:0 | |
Slovakia