| 2. Round | 25/07/2021 | NK Maribor | - | NK Domžale | 3:1 | ||||
| 3. Round | 01/08/2021 | NK Domžale | - | NK Tabor Sežana | 1:1 | ||||
| 1. Round | 25/08/2021 | NK Domžale | - | Olimpija Ljubljana | 0:2 | ||||
| 9. Round | 18/09/2021 | NK Domžale | - | NK Radomlje | 2:0 | ||||
| 23. Round | 26/02/2022 | NK Domžale | - | NK Bravo | 3:0 | ||||
| 28. Round | 20/03/2022 | Olimpija Ljubljana | - | NK Domžale | 1:1 | ||||
| 29. Round | 02/04/2022 | NK Domžale | - | NK Maribor | 0:2 | ||||
| 30. Round | 10/04/2022 | NK Tabor Sežana | - | NK Domžale | 2:1 | ||||
| 31. Round | 16/04/2022 | NK Domžale | - | FC Koper | 0:1 | ||||
| 34. Round | 08/05/2022 | NŠ Mura | - | NK Domžale | 3:1 | ||||
| 36. Round | 21/05/2022 | NK Radomlje | - | NK Domžale | 3:3 |
Slovenia