| 5. Round | 08/08/2021 | Louisville City FC | - | Sporting Kansas City 2 | 4:1 | ||||
| 5. Round | 12/08/2021 | Birmingham Legion | - | Sporting Kansas City 2 | 4:2 | ||||
| 5. Round | 14/08/2021 | Sporting Kansas City 2 | - | Atlanta United II | 1:4 | ||||
| 6. Round | 02/09/2021 | Sporting Kansas City 2 | - | Birmingham Legion | 0:1 | ||||
| 6. Round | 12/09/2021 | Indy Eleven | - | Sporting Kansas City 2 | 1:0 | ||||
| 7. Round | 14/10/2021 | Sporting Kansas City 2 | - | Atlanta United II | 0:3 dec. | ||||
| 7. Round | 24/10/2021 | Birmingham Legion | - | Sporting Kansas City 2 | 6:0 | ||||
| 7. Round | 31/10/2021 | Oakland Roots | - | Sporting Kansas City 2 | 1:0 |
USA