| Copa Libertadores | Matches | W | D | L |  |
 |
 |
| home | 2 | - | 1 | 1 | 6 | - | - |
| away | 3 | - | 1 | 2 | 5 | - | - |
| overall | 5 | - | 2 | 3 | 11 | - | - |
| Copa Libertadores | Home | - | Guest | |
|
|
Results |
| 10/04/15 | Atlético Mineiro | - | Santa Fe | 1 | - | - | 2:0 |
| 05/05/17 | Santos FC | - | Santa Fe | 2 | - | - | 3:2 |
| 19/04/18 | Flamengo RJ | - | Santa Fe | 2 | - | - | 1:1 |
| 29/04/21 | Santa Fe | - | Fluminense RJ | 2 | - | - | 1:2 |
| 26/05/21 | Santa Fe | - | Atlético Junior | 4 | - | - | 0:0 |
Uruguay