| Copa Libertadores | Matches | W | D | L |  |
 |
 |
| home | 4 | 4 | - | - | 5 | - | 1 |
| away | 4 | 1 | 1 | 2 | 9 | - | - |
| overall | 8 | 5 | 1 | 2 | 14 | - | 1 |
| Copa Libertadores | Home | - | Guest | |
|
|
Results |
| 05/06/03 | Santos FC | - | Independiente Medellín | 1 | - | - | 1:0 |
| 11/05/04 | Santos FC | - | LDU Quito | 1 | - | - | 5:3 pso |
| 17/03/05 | LDU Quito | - | Santos FC | - | - | - | 2:1 |
| 10/05/07 | Santos FC | - | Caracas FC | - | - | 1 | 3:2 |
| 05/03/08 | Santos FC | - | Deportivo Guadalajara | 3 | - | - | 1:0 |
| 09/05/08 | Cúcuta Deportivo | - | Santos FC | 2 | - | - | 0:2 |
| 16/06/11 | Peñarol | - | Santos FC | 2 | - | - | 0:0 |
| 18/05/12 | Vélez Sarsfield | - | Santos FC | 5 | - | - | 1:0 |
Paraguay