| Copa Libertadores | Matches | W | D | L |  |
 |
 |
| home | 3 | - | 2 | 1 | 5 | 1 | - |
| away | 3 | 2 | - | 1 | 4 | 1 | - |
| overall | 6 | 2 | 2 | 2 | 9 | 2 | - |
| Copa Sudamericana | Matches | W | D | L | |
|
|
| home | 2 | 2 | - | - | 6 | - | - |
| away | 1 | - | - | 1 | 2 | - | 2 |
| overall | 3 | 2 | - | 1 | 8 | - | 2 |
| Copa Libertadores | Home | - | Guest | |
|
|
Results |
| 06/04/00 | Universidad de Chile | - | River Plate | 3 | - | - | 1:1 |
| 22/04/05 | Universidad de Chile | - | São Paulo FC | 2 | - | - | 1:1 |
| 16/04/09 | Universidad de Chile | - | Grêmio Porto Alegre | - | 1 | - | 0:2 |
| 13/05/10 | Flamengo RJ | - | Universidad de Chile | 1 | 1 | - | 2:3 |
| 05/04/12 | Godoy Cruz | - | Universidad de Chile | 2 | - | - | 0:1 |
| 18/03/15 | The Strongest | - | Universidad de Chile | 1 | - | - | 5:3 |
| Copa Sudamericana | Home | - | Guest | |
|
|
Results |
| 01/10/09 | Universidad de Chile | - | Internacional | 3 | - | - | 1:0 |
| 27/10/11 | Universidad de Chile | - | Flamengo RJ | 3 | - | - | 1:0 |
| 19/09/13 | Lanús | - | Universidad de Chile | 2 | - | 2 | 4:0 |
Paraguay