| Copa Libertadores | Matches | W | D | L |  |
 |
 |
| home | 3 | 2 | - | 1 | 2 | - | - |
| away | - | - | - | - | - | - | - |
| overall | 3 | 2 | - | 1 | 2 | - | - |
| Copa Sudamericana | Matches | W | D | L | |
|
|
| home | 3 | 3 | - | - | 7 | - | - |
| away | 1 | - | 1 | - | 2 | - | - |
| overall | 4 | 3 | 1 | - | 9 | - | - |
| Copa Libertadores | Home | - | Guest | |
|
|
Results |
| 11/02/09 | Defensor Sporting | - | América de Cali | - | - | - | 1:0 |
| 07/02/12 | Defensor Sporting | - | Vélez Sarsfield | 1 | - | - | 0:3 |
| 16/05/14 | Defensor Sporting | - | Atlético Nacional | 1 | - | - | 1:0 |
| Copa Sudamericana | Home | - | Guest | |
|
|
Results |
| 20/08/08 | Defensor Sporting | - | Libertad | 2 | - | - | 2:1 |
| 03/09/10 | Club Olimpia | - | Defensor Sporting | 2 | - | - | 1:1 |
| 26/08/15 | Defensor Sporting | - | Universitario de Deportes | - | - | - | 3:0 |
| 02/10/15 | Defensor Sporting | - | Lanús | 5 | - | - | 5:3 pso |
Chile