| Copa Libertadores | Matches | W | D | L |  |
 |
 |
| home | - | - | - | - | - | - | - |
| away | 4 | - | 1 | 3 | 11 | 1 | 2 |
| overall | 4 | - | 1 | 3 | 11 | 1 | 2 |
| Copa Sudamericana | Matches | W | D | L | |
|
|
| home | 1 | 1 | - | - | 2 | - | - |
| away | - | - | - | - | - | - | - |
| overall | 1 | 1 | - | - | 2 | - | - |
| Copa Libertadores | Home | - | Guest | |
|
|
Results |
| 27/01/06 | Defensor Sporting | - | Santa Fe | 3 | - | - | 2:2 |
| 21/03/06 | Estudiantes | - | Santa Fe | 3 | - | - | 1:0 |
| 03/07/13 | Club Olimpia | - | Santa Fe | 3 | - | 1 | 2:0 |
| 21/04/16 | Cerro Porteño | - | Santa Fe | 2 | 1 | 1 | 1:0 |
| Copa Sudamericana | Home | - | Guest | |
|
|
Results |
| 10/12/15 | Santa Fe | - | Huracán | 2 | - | - | 3:1 pso |
Brazil