| Copa Libertadores | Matches | W | D | L |  |
 |
 |
| home | 4 | 1 | 1 | 2 | 10 | - | 1 |
| away | - | - | - | - | - | - | - |
| overall | 4 | 1 | 1 | 2 | 10 | - | 1 |
| Copa Mercosur | Matches | W | D | L | |
|
|
| home | 1 | 1 | - | - | 2 | - | - |
| away | - | - | - | - | - | - | - |
| overall | 1 | 1 | - | - | 2 | - | - |
| Copa Libertadores | Home | - | Guest | |
|
|
Results |
| 04/02/04 | Colo-Colo | - | Deportivo Cali | 2 | - | - | 2:3 |
| 09/05/07 | Colo-Colo | - | CF América | 3 | - | 1 | 2:1 |
| 23/04/08 | Colo-Colo | - | Atlas Guadalajara | 1 | - | - | 1:1 |
| 21/04/11 | Colo-Colo | - | Cerro Porteño | 4 | - | - | 2:3 |
| Copa Mercosur | Home | - | Guest | |
|
|
Results |
| 08/08/00 | Colo-Colo | - | São Paulo FC | 2 | - | - | 3:1 |
Uruguay