| Copa Sudamericana | Matches | W | D | L |  |
 |
 |
| home | 1 | 1 | - | - | 4 | - | - |
| away | 1 | - | 1 | - | 4 | - | - |
| overall | 2 | 1 | 1 | - | 8 | - | - |
| Copa Sudamericana | Home | - | Guest | |
|
|
Results |
| 17/08/18 | Colón de Santa Fe | - | São Paulo FC | 4 | - | - | 5:3 pso |
| 22/05/19 | River Plate | - | Colón de Santa Fe | 4 | - | - | 0:0 |
Paraguay