| Copa Libertadores | Matches | W | D | L |  |
 |
 |
| home | 2 | 2 | - | - | 6 | 1 | 2 |
| away | 3 | 2 | 1 | - | 11 | - | - |
| overall | 5 | 4 | 1 | - | 17 | 1 | 2 |
| Copa Libertadores | Home | - | Guest | |
|
|
Results |
| 22/03/07 | Gimnasia de La Plata | - | Santos FC | 4 | - | - | 1:2 |
| 17/05/07 | CF América | - | Santos FC | 4 | - | - | 0:0 |
| 07/04/11 | Santos FC | - | Colo-Colo | 2 | 1 | 2 | 3:2 |
| 15/03/12 | Juan Aurich | - | Santos FC | 3 | - | - | 1:3 |
| 25/05/12 | Santos FC | - | Vélez Sarsfield | 4 | - | - | 4:2 pso |
Uruguay