| Copa Libertadores | Matches | W | D | L |  |
 |
 |
| home | 2 | 2 | - | - | 4 | - | - |
| away | 3 | 1 | 1 | 1 | 4 | 2 | - |
| overall | 5 | 3 | 1 | 1 | 8 | 2 | - |
| Copa Sudamericana | Matches | W | D | L | |
|
|
| home | 1 | 1 | - | - | 2 | - | - |
| away | - | - | - | - | - | - | - |
| overall | 1 | 1 | - | - | 2 | - | - |
| Copa Libertadores | Home | - | Guest | |
|
|
Results |
| 02/06/11 | Cerro Porteño | - | Santos FC | 3 | 1 | - | 3:3 |
| 02/05/18 | Nacional | - | Santos FC | 1 | 1 | - | 1:0 |
| 16/12/20 | Santos FC | - | Grêmio Porto Alegre | 3 | - | - | 4:1 |
| 13/01/21 | Santos FC | - | Boca Juniors | 1 | - | - | 3:0 |
| 07/04/21 | San Lorenzo | - | Santos FC | - | - | - | 1:3 |
| Copa Sudamericana | Home | - | Guest | |
|
|
Results |
| 16/07/21 | Santos FC | - | Independiente | 2 | - | - | 1:0 |
Colombia