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| 1st(1st leg) | KS Kamza | - | Dinamo Tiranë | 2:3 (0:0) | ||
| 2nd (2nd leg) | Dinamo Tiranë | - | KS Kamza | 2:0 (1:0) | ||
| 1st(1st leg): 24/11/2010 12:00 | 2nd (2nd leg): 08/12/2010 12:00 | Winner: Dinamo Tiranë | ||||
| 1st(1st leg) | KF Ada Velipojë | - | KF Tiranë | 0:3 (0:0) | ||
| 2nd (2nd leg) | KF Tiranë | - | KF Ada Velipojë | 2:2 (0:0) | ||
| 1st(1st leg): 24/11/2010 12:00 | 2nd (2nd leg): 08/12/2010 12:00 | Winner: KF Tiranë | ||||
| 1st(1st leg) | KF Bylis Ballsh | - | Flamurtari Vlorë | 0:0 (0:0) | ||
| 2nd (2nd leg) | Flamurtari Vlorë | - | KF Bylis Ballsh | 0:1 (0:1) | ||
| 1st(1st leg): 24/11/2010 12:00 | 2nd (2nd leg): 08/12/2010 12:00 | Winner: KF Bylis Ballsh | ||||
| 1st(1st leg) | KF Lushnja | - | KS Besa | 0:0 (0:0) | ||
| 2nd (2nd leg) | KS Besa | - | KF Lushnja | 1:0 (0:0) | ||
| 1st(1st leg): 24/11/2010 12:00 | 2nd (2nd leg): 08/12/2010 12:00 | Winner: KS Besa | ||||
| 1st(1st leg) | KS Gramozi | - | KF Laçi | 2:2 (0:1) | ||
| 2nd (2nd leg) | KF Laçi | - | KS Gramozi | 4:0 (0:0) | ||
| 1st(1st leg): 24/11/2010 12:00 | 2nd (2nd leg): 08/12/2010 12:00 | Winner: KF Laçi | ||||
| 1st(1st leg) | KF Elbasani | - | FK Vllaznia | 0:1 (0:0) | ||
| 2nd (2nd leg) | FK Vllaznia | - | KF Elbasani | 4:0 (3:0) | ||
| 1st(1st leg): 24/11/2010 12:00 | 2nd (2nd leg): 08/12/2010 12:00 | Winner: FK Vllaznia | ||||
| 1st(1st leg) | KS Kastrioti | - | KS Shkumbini | 1:3 (0:0) | ||
| 2nd (2nd leg) | KS Shkumbini | - | KS Kastrioti | 2:2 (1:1) | ||
| 1st(1st leg): 25/11/2010 12:00 | 2nd (2nd leg): 08/12/2010 12:00 | Winner: KS Shkumbini | ||||
| 1st(1st leg) | KF Skënderbeu | - | KF Teuta Durrës | 0:0 (0:0) | ||
| 2nd (2nd leg) | KF Teuta Durrës | - | KF Skënderbeu | 0:2 (0:0) | ||
| 1st(1st leg): 25/11/2010 12:00 | 2nd (2nd leg): 08/12/2010 12:00 | Winner: KF Skënderbeu | ||||
