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| 1st(1st leg) | Germinal Beerschot | - | KSV Roeselare | 5:1 | ||
| 2nd (2nd leg) | KSV Roeselare | - | Germinal Beerschot | 1:1 | ||
| 1st(1st leg): 30/01/2008 19:30 | 2nd (2nd leg): 27/02/2008 19:30 | Winner: Germinal Beerschot | ||||
| 1st(1st leg) | KV Kortrijk | - | KAA Gent | 5:1 | ||
| 2nd (2nd leg) | KAA Gent | - | KV Kortrijk | 4:0 | ||
| 1st(1st leg): 30/01/2008 19:30 | 2nd (2nd leg): 27/02/2008 19:30 | Winner: KAA Gent | ||||
| 1st(1st leg) | RSC Anderlecht | - | FCV Dender EH | 3:0 | ||
| 2nd (2nd leg) | FCV Dender EH | - | RSC Anderlecht | 1:1 | ||
| 1st(1st leg): 30/01/2008 19:30 | 2nd (2nd leg): 27/02/2008 19:30 | Winner: RSC Anderlecht | ||||
| 1st(1st leg) | Cercle Brugge | - | Standard Liège | 4:1 | ||
| 2nd (2nd leg) | Standard Liège | - | Cercle Brugge | 4:0 | ||
| 1st(1st leg): 30/01/2008 19:45 | 2nd (2nd leg): 27/02/2008 19:45 | Winner: Standard Liège | ||||
