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| 04/03/2000 | 19:00 | Sint-Truidense VV | - | KV Mechelen | 3:1 (1:0) | |
| 19:00 | Sporting Lokeren | - | KRC Harelbeke | 2:0 (0:0) | ||
| 19:00 | Verbroedering Geel | - | K.S.C. Eendracht Aalst | 1:2 (0:0) | ||
| 19:00 | Excelsior Mouscron | - | RSC Charleroi | 2:1 (0:0) | ||
| 19:00 | KSK Beveren | - | Standard Liège | 0:2 (0:0) | ||
| 19:00 | Lierse SK | - | KRC Genk | 5:0 (4:0) | ||
| 19:00 | Lommelse SK | - | KAA Gent | 1:3 (0:1) | ||
| 05/03/2000 | 14:00 | Club Brugge KV | - | KVC Westerlo | 2:0 (2:0) | |
| 19:00 | Germinal Beerschot | - | RSC Anderlecht | 1:3 (0:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RSC Anderlecht | 25 | 18 | 6 | 1 | 67:24 | 43 | 60 |
| 2 |
|
Standard Liège | 25 | 16 | 2 | 7 | 57:36 | 21 | 50 |
| 3 |
|
Club Brugge KV | 25 | 14 | 4 | 7 | 54:25 | 29 | 46 |
| 4 |
|
KAA Gent | 25 | 15 | 1 | 9 | 61:45 | 16 | 46 |
| 5 |
|
Lierse SK | 25 | 13 | 5 | 7 | 53:31 | 22 | 44 |
| 6 |
|
Excelsior Mouscron | 25 | 13 | 4 | 8 | 53:37 | 16 | 43 |
| 7 |
|
KRC Genk | 25 | 12 | 6 | 7 | 51:42 | 9 | 42 |
| 8 |
|
Germinal Beerschot | 25 | 12 | 6 | 7 | 43:36 | 7 | 42 |
| 9 |
|
KVC Westerlo | 25 | 10 | 6 | 9 | 45:55 | -10 | 36 |
| 10 |
|
Sporting Lokeren | 25 | 9 | 6 | 10 | 44:50 | -6 | 33 |
| 11 |
|
KV Mechelen | 25 | 10 | 3 | 12 | 40:56 | -16 | 33 |
| 12 |
|
K.S.C. Eendracht Aalst | 25 | 10 | 2 | 13 | 45:51 | -6 | 32 |
| 13 |
|
KRC Harelbeke | 25 | 7 | 4 | 14 | 42:52 | -10 | 25 |
| 14 |
|
KSK Beveren | 25 | 6 | 6 | 13 | 35:48 | -13 | 24 |
| 15 |
|
Sint-Truidense VV | 25 | 6 | 4 | 15 | 27:53 | -26 | 22 |
| 16 |
|
RSC Charleroi | 25 | 5 | 6 | 14 | 29:50 | -21 | 21 |
| 17 |
|
Verbroedering Geel | 25 | 3 | 9 | 13 | 20:45 | -25 | 18 |
| 18 |
|
Lommelse SK | 25 | 1 | 10 | 14 | 23:53 | -30 | 13 |
