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| 1st(1st leg) | Zvijezda Gradačac | - | Igman Konjic | 0:1 (0:0) | ||
| 2nd (2nd leg) | Igman Konjic | - | Zvijezda Gradačac | 3:1 (2:0) | ||
| 1st(1st leg): 02/03/2022 12:00 | 2nd (2nd leg): 16/03/2022 13:30 | Winner: Igman Konjic | ||||
| 1st(1st leg) | FK Tuzla City | - | Borac Banja Luka | 0:1 (0:1) | ||
| 2nd (2nd leg) | Borac Banja Luka | - | FK Tuzla City | 3:4 (1:0, 1:2) pso | ||
| 1st(1st leg): 02/03/2022 14:00 | 2nd (2nd leg): 16/03/2022 15:00 | Winner: FK Tuzla City | ||||
| 1st(1st leg) | FK Sarajevo | - | Sloboda Tuzla | 2:0 (1:0) | ||
| 2nd (2nd leg) | Sloboda Tuzla | - | FK Sarajevo | 0:0 (0:0) | ||
| 1st(1st leg): 02/03/2022 16:00 | 2nd (2nd leg): 16/03/2022 13:00 | Winner: FK Sarajevo | ||||
| 1st(1st leg) | Velež Mostar | - | Široki Brijeg | 4:0 (1:0) | ||
| 2nd (2nd leg) | Široki Brijeg | - | Velež Mostar | 1:0 (0:0) | ||
| 1st(1st leg): 02/03/2022 18:00 | 2nd (2nd leg): 16/03/2022 17:30 | Winner: Velež Mostar | ||||
