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| 05/11/2021 | 15:00 | Rukh Brest | - | FK Vitebsk | 2:0 (1:0) | |
| 06/11/2021 | Sputnik Rechytsa | - | Torpedo-BelAZ Zhodino | 0:3 dec. | ||
| 10:00 | Energetik-BGU Minsk | - | FK Minsk | 1:1 (0:1) | ||
| 12:00 | BATE Borisov | - | Dinamo Minsk | 1:1 (0:0) | ||
| 14:00 | Shakhter Soligorsk | - | FK Slutsk | 1:1 (1:0) | ||
| 07/11/2021 | 10:00 | FK Isloch Minsk | - | FK Gomel | 1:2 (1:0) | |
| 12:00 | FK Smorgon | - | Dinamo Brest | 1:1 (0:1) | ||
| 14:00 | FK Slaviya Mozyr | - | Neman Grodno | 1:1 (0:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Shakhter Soligorsk | 28 | 23 | 3 | 2 | 59:17 | 42 | 72 |
| 2 |
|
BATE Borisov | 28 | 17 | 8 | 3 | 54:27 | 27 | 59 |
| 3 |
|
Dinamo Minsk | 28 | 18 | 4 | 6 | 53:20 | 33 | 58 |
| 4 |
|
FK Gomel | 28 | 16 | 7 | 5 | 56:23 | 33 | 55 |
| 5 |
|
Rukh Brest | 28 | 15 | 10 | 3 | 49:23 | 26 | 55 |
| 6 |
|
Dinamo Brest | 28 | 8 | 14 | 6 | 30:26 | 4 | 38 |
| 7 |
|
Torpedo-BelAZ Zhodino | 28 | 10 | 6 | 12 | 37:37 | 0 | 36 |
| 8 |
|
FK Vitebsk | 28 | 8 | 10 | 10 | 34:37 | -3 | 34 |
| 9 |
|
FK Isloch Minsk | 28 | 9 | 7 | 12 | 38:42 | -4 | 34 |
| 10 |
|
Neman Grodno | 28 | 8 | 7 | 13 | 33:33 | 0 | 31 |
| 11 |
|
FK Minsk | 28 | 7 | 9 | 12 | 31:51 | -20 | 30 |
| 12 |
|
Energetik-BGU Minsk | 28 | 7 | 9 | 12 | 29:39 | -10 | 30 |
| 13 |
|
FK Slutsk | 28 | 7 | 8 | 13 | 30:44 | -14 | 29 |
| 14 |
|
FK Slaviya Mozyr | 28 | 7 | 7 | 14 | 39:48 | -9 | 28 |
| 15 |
|
FK Smorgon | 28 | 3 | 8 | 17 | 25:66 | -41 | 17 |
| 16 |
|
Sputnik Rechytsa | 28 | 2 | 1 | 25 | 12:76 | -64 | 7 |
| Champions League Quali. | |
| Playoffs | |
| Relegation |
