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| 22/05/2021 | 11:00 | Falko Cherkassy | - | FK Molodechno | 2:7 | |
| 12:00 | FK Kobrin | - | FK Krechet Byaroza | 3:2 | ||
| 12:00 | FK Postavy | - | FK Gazovik | 0:1 | ||
| 12:00 | Khimik Svetlogorsk | - | Maxline Rogachev | 1:3 | ||
| 12:00 | FK Osipovichi | - | FK Gorki | 2:1 | ||
| 13:00 | Dyush-3 Stenles Pinsk | - | FK Luninets | 5:0 | ||
| 13:00 | FK Lepel | - | FK Niva Tolochin | 3:1 | ||
| 13:00 | SMI Autotrans | - | FK Smolevichy-STI | 1:3 | ||
| 14:00 | FK Malorita | - | FC Brestzhilstroy | 4:2 | ||
| 15:00 | Stroitel Kopyl | - | BGU Minsk | 2:1 | ||
| 15:30 | Klechesk Kletsk | - | Kronon Stolbtsy | 0:3 | ||
| 23/05/2021 | 11:00 | DYuSSh Stolin | - | Ivatsevichi | 2:8 | |
| 12:00 | FK Gorodokskiye L'vy | - | FK Senno | 0:1 | ||
| 13:00 | FK Leskhoz | - | Montazhnik Mozyr | 4:1 | ||
| 14:00 | Neman Mosty | - | Tsementnik Krasnoselsky | 3:5 | ||
| 14:00 | Partizan Soligorsk | - | FK Starye Dorogi | 5:1 | ||
| 16:00 | ZhKKh Grodno | - | Ostrovets FC | 0:2 | ||
| 16:00 | Spartak Shklov | - | Kostyukovichy | 1:2 | ||
| 16:00 | FK Belita-Vitex Uzda | - | Krupki DRSU 164 | 5:1 | ||
| 17:00 | Oshmyany FK | - | FSK Grodnensky | 1:2 |
