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| 1st(1st leg) | Atlético Nacional | - | Santa Fe | 3:0 (2:0) | ||
| 2nd (2nd leg) | Santa Fe | - | Atlético Nacional | 2:0 (0:0) | ||
| 1st(1st leg): 25/07/2019 01:30 | 2nd (2nd leg): 16/08/2019 02:00 | Winner: Atlético Nacional | ||||
| 1st(1st leg) | Águilas Doradas | - | Deportivo Pereira | 1:1 (0:1) | ||
| 2nd (2nd leg) | Deportivo Pereira | - | Águilas Doradas | 1:0 (1:0) | ||
| 1st(1st leg): 31/07/2019 22:00 | 2nd (2nd leg): 14/08/2019 22:00 | Winner: Deportivo Pereira | ||||
| 1st(1st leg) | Deportivo Cali | - | Real San Andrés | 1:0 (1:0) | ||
| 2nd (2nd leg) | Real San Andrés | - | Deportivo Cali | 0:1 (0:0) | ||
| 1st(1st leg): 01/08/2019 01:30 | 2nd (2nd leg): 14/08/2019 21:30 | Winner: Deportivo Cali | ||||
| 1st(1st leg) | Once Caldas | - | América de Cali | 2:1 (1:1) | ||
| 2nd (2nd leg) | América de Cali | - | Once Caldas | 0:0 (0:0) | ||
| 1st(1st leg): 01/08/2019 01:30 | 2nd (2nd leg): 15/08/2019 00:00 | Winner: Once Caldas | ||||
| 1st(1st leg) | La Equidad | - | Deportivo Pasto | 3:2 (2:2) | ||
| 2nd (2nd leg) | Deportivo Pasto | - | La Equidad | 4:3 (2:0, 2:1, 2:1) pso | ||
| 1st(1st leg): 01/08/2019 01:30 | 2nd (2nd leg): 14/08/2019 21:00 | Winner: Deportivo Pasto | ||||
| 1st(1st leg) | Deportes Tolima | - | Orsomarso SC | 3:0 (1:0) | ||
| 2nd (2nd leg) | Orsomarso SC | - | Deportes Tolima | 0:5 (0:1) | ||
| 1st(1st leg): 07/08/2019 21:45 | 2nd (2nd leg): 14/08/2019 21:30 | Winner: Deportes Tolima | ||||
| 1st(1st leg) | Independiente Medellín | - | Millonarios | 2:1 (1:0) | ||
| 2nd (2nd leg) | Millonarios | - | Independiente Medellín | 2:2 (2:1) | ||
| 1st(1st leg): 08/08/2019 01:30 | 2nd (2nd leg): 15/08/2019 02:00 | Winner: Independiente Medellín | ||||
| 1st(1st leg) | Atlético Junior | - | Atlético Bucaramanga | 2:0 (2:0) | ||
| 2nd (2nd leg) | Atlético Bucaramanga | - | Atlético Junior | 1:2 (1:1) | ||
| 1st(1st leg): 09/08/2019 01:30 | 2nd (2nd leg): 16/08/2019 00:00 | Winner: Atlético Junior | ||||
