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| 1st(1st leg) | La Equidad | - | Águilas Doradas | 1:0 (0:0) | ||
| 2nd (2nd leg) | Águilas Doradas | - | La Equidad | 5:4 (2:1) pso | ||
| 1st(1st leg): 26/07/2023 01:00 | 2nd (2nd leg): 17/08/2023 00:00 | Winner: Águilas Doradas | ||||
| 1st(1st leg) | Tigres FC | - | Deportivo Pereira | 0:1 (0:0) | ||
| 2nd (2nd leg) | Deportivo Pereira | - | Tigres FC | 1:0 (0:0) | ||
| 1st(1st leg): 26/07/2023 21:30 | 2nd (2nd leg): 17/08/2023 01:00 | Winner: Deportivo Pereira | ||||
| 1st(1st leg) | Alianza Petrolera | - | Deportes Tolima | 2:0 (1:0) | ||
| 2nd (2nd leg) | Deportes Tolima | - | Alianza Petrolera | 2:0 (0:0) pso | ||
| 1st(1st leg): 27/07/2023 00:30 | 2nd (2nd leg): 17/08/2023 01:00 | Winner: Deportes Tolima | ||||
| 1st(1st leg) | América de Cali | - | Atlético Nacional | 1:3 (1:2) | ||
| 2nd (2nd leg) | Atlético Nacional | - | América de Cali | 2:1 (1:1) | ||
| 1st(1st leg): 27/07/2023 02:00 | 2nd (2nd leg): 18/08/2023 02:30 | Winner: Atlético Nacional | ||||
| 1st(1st leg) | Cúcuta Deportivo | - | Atlético Junior | 4:3 (1:0) | ||
| 2nd (2nd leg) | Atlético Junior | - | Cúcuta Deportivo | 3:4 (1:0) pso | ||
| 1st(1st leg): 27/07/2023 22:00 | 2nd (2nd leg): 17/08/2023 02:30 | Winner: Cúcuta Deportivo | ||||
| 1st(1st leg) | Deportivo Cali | - | Santa Fe | 2:1 (0:0) | ||
| 2nd (2nd leg) | Santa Fe | - | Deportivo Cali | 3:1 (0:0) pso | ||
| 1st(1st leg): 28/07/2023 02:00 | 2nd (2nd leg): 17/08/2023 00:00 | Winner: Santa Fe | ||||
| 1st(1st leg) | Independiente Medellín | - | Deportivo Pasto | 3:1 (2:1) | ||
| 2nd (2nd leg) | Deportivo Pasto | - | Independiente Medellín | 3:1 (0:1) | ||
| 1st(1st leg): 10/08/2023 01:00 | 2nd (2nd leg): 18/08/2023 00:00 | |||||
| 1st(1st leg) | Millonarios | - | Atlético Bucaramanga | 3:1 (0:1) | ||
| 2nd (2nd leg) | Atlético Bucaramanga | - | Millonarios | 0:0 (0:0) | ||
| 1st(1st leg): 11/08/2023 02:10 | 2nd (2nd leg): 18/08/2023 00:00 | Winner: Millonarios | ||||
