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| 1st(1st leg) | La Equidad | - | Deportes Tolima | 2:2 (1:0) | ||
| 2nd (2nd leg) | Deportes Tolima | - | La Equidad | 1:3 (1:1, 1:1, 1:1) pso | ||
| 1st(1st leg): 20/05/2010 01:30 | 2nd (2nd leg): 23/05/2010 00:20 | Winner: La Equidad | ||||
| 1st(1st leg) | Atlético Junior | - | Independiente Medellín | 3:1 (2:1) | ||
| 2nd (2nd leg) | Independiente Medellín | - | Atlético Junior | 1:0 (1:0) | ||
| 1st(1st leg): 21/05/2010 01:30 | 2nd (2nd leg): 23/05/2010 23:45 | Winner: Atlético Junior | ||||
