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| 1st(1st leg) | Independiente Medellín | - | Deportes Tolima | 2:2 (0:1) | ||
| 2nd (2nd leg) | Deportes Tolima | - | Independiente Medellín | 0:2 (0:0) | ||
| 1st(1st leg): 22/11/2018 00:00 | 2nd (2nd leg): 26/11/2018 00:30 | Winner: Independiente Medellín | ||||
| 1st(1st leg) | Águilas Doradas | - | Atlético Junior | 2:3 (0:0) | ||
| 2nd (2nd leg) | Atlético Junior | - | Águilas Doradas | 1:1 (1:0) | ||
| 1st(1st leg): 23/11/2018 00:45 | 2nd (2nd leg): 25/11/2018 22:15 | Winner: Atlético Junior | ||||
