 |
 |
| 1st(1st leg) | Deportivo Cali | - | Deportes Tolima | 1:1 (1:0) | ||
| 2nd (2nd leg) | Deportes Tolima | - | Deportivo Cali | 1:0 (0:0) | ||
| 1st(1st leg): 10/02/2022 01:00 | 2nd (2nd leg): 24/02/2022 01:00 | Winner: Deportes Tolima | ||||
|
|
| 1st(1st leg) | Deportivo Cali | - | Deportes Tolima | 1:1 (1:0) | ||
| 2nd (2nd leg) | Deportes Tolima | - | Deportivo Cali | 1:0 (0:0) | ||
| 1st(1st leg): 10/02/2022 01:00 | 2nd (2nd leg): 24/02/2022 01:00 | Winner: Deportes Tolima | ||||
