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| 1st(1st leg) | FC Cincinnati | - | UANL Tigres | 1:1 (1:1) | ||
| 2nd (2nd leg) | UANL Tigres | - | FC Cincinnati | 3:1 (0:1) | ||
| 1st(1st leg): 04/03/2025 23:30 | 2nd (2nd leg): 12/03/2025 02:30 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Pumas UNAM | - | LD Alajuelense | 2:0 (1:0) | ||
| 2nd (2nd leg) | LD Alajuelense | - | Pumas UNAM | 1:1 (1:0) | ||
| 1st(1st leg): 05/03/2025 01:30 | 2nd (2nd leg): 14/03/2025 02:00 | Winner: Pumas UNAM | ||||
| 1st(1st leg) | Los Angeles FC | - | Columbus Crew | 3:0 (1:0) | ||
| 2nd (2nd leg) | Columbus Crew | - | Los Angeles FC | 2:1 (2:0) | ||
| 1st(1st leg): 05/03/2025 03:30 | 2nd (2nd leg): 12/03/2025 00:30 | Winner: Los Angeles FC | ||||
| 1st(1st leg) | Deportivo Guadalajara | - | CF América | 1:0 (0:0) | ||
| 2nd (2nd leg) | CF América | - | Deportivo Guadalajara | 4:0 (2:0) | ||
| 1st(1st leg): 06/03/2025 01:30 | 2nd (2nd leg): 13/03/2025 02:30 | Winner: CF América | ||||
| 1st(1st leg) | CS Herediano | - | Los Angeles Galaxy | 1:0 (0:0) | ||
| 2nd (2nd leg) | Los Angeles Galaxy | - | CS Herediano | 4:1 (2:0) | ||
| 1st(1st leg): 06/03/2025 01:30 | 2nd (2nd leg): 13/03/2025 02:30 | Winner: Los Angeles Galaxy | ||||
| 1st(1st leg) | Seattle Sounders | - | Cruz Azul | 0:0 (0:0) | ||
| 2nd (2nd leg) | Cruz Azul | - | Seattle Sounders | 4:1 (1:0) | ||
| 1st(1st leg): 06/03/2025 03:30 | 2nd (2nd leg): 12/03/2025 00:30 | Winner: Cruz Azul | ||||
| 1st(1st leg) | Vancouver Whitecaps | - | CF Monterrey | 1:1 (0:1) | ||
| 2nd (2nd leg) | CF Monterrey | - | Vancouver Whitecaps | 2:2 (1:0) | ||
| 1st(1st leg): 06/03/2025 03:30 | 2nd (2nd leg): 13/03/2025 00:30 | Winner: Vancouver Whitecaps | ||||
| 1st(1st leg) | Inter Miami CF | - | Cavalier FC | 2:0 (0:0) | ||
| 2nd (2nd leg) | Cavalier FC | - | Inter Miami CF | 0:2 (0:1) | ||
| 1st(1st leg): 07/03/2025 01:00 | 2nd (2nd leg): 14/03/2025 00:00 | Winner: Inter Miami CF | ||||
