1st(1st leg) Marathón - Portland Timbers -:-
2nd (2nd leg) Portland Timbers - Marathón -:-
1st(1st leg): 06/04/2021 23:00 2nd (2nd leg): 14/04/2021 01:00
1st(1st leg) LD Alajuelense - Atlanta United FC -:-
2nd (2nd leg) Atlanta United FC - LD Alajuelense -:-
1st(1st leg): 07/04/2021 01:00 2nd (2nd leg): 13/04/2021 23:00
1st(1st leg) Arcahaie FC - Cruz Azul -:-
2nd (2nd leg) Cruz Azul - Arcahaie FC -:-
1st(1st leg): 07/04/2021 03:00 2nd (2nd leg): 14/04/2021 03:00
1st(1st leg) Deportivo Saprissa - Philadelphia Union -:-
2nd (2nd leg) Philadelphia Union - Deportivo Saprissa -:-
1st(1st leg): 07/04/2021 23:00 2nd (2nd leg): 15/04/2021 01:00
1st(1st leg) Club León - Forge / Toronto -:-
2nd (2nd leg) Forge / Toronto - Club León -:-
1st(1st leg): 08/04/2021 01:00 2nd (2nd leg): 14/04/2021 23:00
1st(1st leg) Olimpia - CF América -:-
2nd (2nd leg) CF América - Olimpia -:-
1st(1st leg): 08/04/2021 03:00 2nd (2nd leg): 15/04/2021 01:00
1st(1st leg) Real Estelí - Columbus Crew -:-
2nd (2nd leg) Columbus Crew - Real Estelí -:-
1st(1st leg): 09/04/2021 01:00 2nd (2nd leg): 16/04/2021 01:00
1st(1st leg) CD Pantoja - CF Monterrey -:-
2nd (2nd leg) CF Monterrey - CD Pantoja -:-
1st(1st leg): 09/04/2021 03:00 2nd (2nd leg): 16/04/2021 03:00