1st(1st leg) Philadelphia Union - Atlas Guadalajara 1:0 (0:0)
2nd (2nd leg) Atlas Guadalajara - Philadelphia Union 2:2 (2:1)
1st(1st leg): 05/04/2023 01:00 2nd (2nd leg): 13/04/2023 03:00 Winner: Philadelphia Union
1st(1st leg) Club León - Violette AC 5:0 (1:0)
2nd (2nd leg) Violette AC - Club León 2:1 (2:1)
1st(1st leg): 05/04/2023 03:00 2nd (2nd leg): 12/04/2023 01:00 Winner: Club León
1st(1st leg) Motagua - UANL Tigres 0:1 (0:1)
2nd (2nd leg) UANL Tigres - Motagua 5:0 (1:0)
1st(1st leg): 06/04/2023 01:00 2nd (2nd leg): 14/04/2023 03:00 Winner: UANL Tigres
1st(1st leg) Vancouver Whitecaps - Los Angeles FC 0:3 (0:0)
2nd (2nd leg) Los Angeles FC - Vancouver Whitecaps 3:0 (2:0)
1st(1st leg): 06/04/2023 03:00 2nd (2nd leg): 12/04/2023 03:15 Winner: Los Angeles FC