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| 21/09/2021 | 22:45 | Inter Moengotapoe | - | Olimpia | 0:6 (0:3) | |
| 22/09/2021 | 01:00 | Forge FC | - | Independiente de La Chorrera | 0:0 (0:0) | |
| 03:00 | Deportivo Guastatoya | - | LD Alajuelense | 1:1 (1:1) | ||
| 23/09/2021 | 01:00 | Comunicaciones | - | Alianza | 2:1 (1:1) | |
| 03:00 | Marathón | - | Real Estelí FC | 2:0 (2:0) | ||
| 23:00 | Santos de Guápiles | - | Plaza Amador | 1:0 (0:0) | ||
| 24/09/2021 | 01:00 | Santa Lucía | - | Deportivo Saprissa | 0:2 (0:2) | |
| 03:00 | UD Universitario | - | Motagua | 2:2 (1:0) | ||
| 29/09/2021 | Olimpia | - | Inter Moengotapoe | annull. | ||
| 28/09/2021 | 23:00 | Independiente de La Chorrera | - | Forge FC | 0:2 (0:1) | |
| 29/09/2021 | 01:15 | LD Alajuelense | - | Deportivo Guastatoya | 2:2 (2:0) | |
| 23:00 | Plaza Amador | - | Santos de Guápiles | 0:2 (0:1) | ||
| 30/09/2021 | 01:15 | Alianza | - | Comunicaciones | 0:1 (0:0) | |
| 03:30 | Real Estelí FC | - | Marathón | 4:5 (1:0, 2:0) pso | ||
| 01/10/2021 | 01:00 | Deportivo Saprissa | - | Santa Lucía | 4:2 (3:2) | |
| 03:15 | Motagua | - | UD Universitario | 1:0 (1:0) |
