1st(1st leg) Real España - LD Alajuelense -:-
2nd (2nd leg) LD Alajuelense - Real España -:-
1st(1st leg): 05/10/2022 02:00 2nd (2nd leg): 12/10/2022 01:00
1st(1st leg) Motagua - Olimpia -:-
2nd (2nd leg) Olimpia - Motagua -:-
1st(1st leg): 06/10/2022 02:00 2nd (2nd leg): 12/10/2022 03:15
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