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| 1st(1st leg) | Ethnikos Achna | - | Enosis Neon Paralimni | 1:0 (0:0) | ||
| 2nd (2nd leg) | Enosis Neon Paralimni | - | Ethnikos Achna | 0:4 (0:1) | ||
| 1st(1st leg): 09/03/2022 15:00 | 2nd (2nd leg): 06/04/2022 15:00 | Winner: Ethnikos Achna | ||||
| 1st(1st leg) | APOEL Nikosia | - | Anorthosis Famagusta | 2:1 (1:1) | ||
| 2nd (2nd leg) | Anorthosis Famagusta | - | APOEL Nikosia | 1:0 (1:0) | ||
| 1st(1st leg): 09/03/2022 17:00 | 2nd (2nd leg): 06/04/2022 17:00 | Winner: Anorthosis Famagusta | ||||
| 1st(1st leg) | AEK Larnaca | - | Onisilos Sotiras | 8:0 (4:0) | ||
| 2nd (2nd leg) | Onisilos Sotiras | - | AEK Larnaca | 1:5 (0:3) | ||
| 1st(1st leg): 16/03/2022 16:00 | 2nd (2nd leg): 13/04/2022 15:00 | Winner: AEK Larnaca | ||||
| 1st(1st leg) | AEL Limassol | - | Omonia Nikosia | 1:1 (0:0) | ||
| 2nd (2nd leg) | Omonia Nikosia | - | AEL Limassol | 0:0 (0:0) | ||
| 1st(1st leg): 16/03/2022 17:00 | 2nd (2nd leg): 13/04/2022 17:00 | Winner: Omonia Nikosia | ||||
