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| 21/09/2021 | 15:30 | Brabrand IF | - | Kolding IF | 0:1 (0:1) | |
| 16:45 | FC Helsingør | - | Odense BK | 0:3 (0:3) | ||
| 17:00 | AB Gladsaxe | - | FC Fredericia | 0:2 (0:2) | ||
| 17:30 | Lyngby BK | - | Aalborg BK | 0:4 (0:2) | ||
| 22/09/2021 | 15:30 | Vanløse IF | - | Vejle BK | 3:4 (1:1) | |
| 15:30 | B 1913 Odense | - | SønderjyskE | 3:4 (0:2) | ||
| 15:30 | Kjellerup IF | - | FC Midtjylland | 0:5 (0:2) | ||
| 15:30 | VSK Aarhus | - | FC Nordsjælland | 1:2 (1:1) | ||
| 15:30 | Aalborg Freja | - | IF Lyseng | 5:4 (1:1, 1:1, 1:1) pso | ||
| 17:00 | Nykøbing FC | - | FC København | 3:0 (2:0) | ||
| 17:00 | Fremad Amager | - | Randers FC | 2:3 (2:3) | ||
| 17:30 | BK Marienlyst | - | Middelfart Boldklub | 1:2 (0:0, 1:1) aet | ||
| 23/09/2021 | 17:00 | BK Frem København | - | Aarhus GF | 0:3 (0:3) | |
| 17:00 | AC Horsens | - | Silkeborg IF | 3:2 (3:1) | ||
| 18:45 | Allerød FK | - | Brøndby IF | 1:8 (0:4) | ||
| 29/09/2021 | 17:15 | FA 2000 | - | Hvidovre IF | 0:3 (0:1) |
