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| 15/09/2021 | 01:00 | Guayaquil SC | - | Liga de Portoviejo | 2:0 (1:0) | |
| 21:00 | Gualaceo SC | - | Cumbayá | 3:1 (1:0) | ||
| 21:00 | Independiente Juniors | - | Chacaritas FC | 2:0 (1:0) | ||
| 21:00 | Atlético Santo Domingo | - | Atlético Porteño | 2:0 (1:0) | ||
| 16/09/2021 | 01:00 | El Nacional | - | América de Quito | 1:4 (1:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cumbayá | 32 | 18 | 7 | 7 | 40:28 | 12 | 61 |
| 2 |
|
Gualaceo SC | 32 | 15 | 8 | 9 | 41:26 | 15 | 53 |
| 3 |
|
El Nacional | 32 | 15 | 8 | 9 | 42:31 | 11 | 53 |
| 4 |
|
América de Quito | 32 | 10 | 14 | 8 | 37:28 | 9 | 44 |
| 5 |
|
Chacaritas FC | 32 | 10 | 12 | 10 | 27:30 | -3 | 42 |
| 6 |
|
Independiente Juniors | 32 | 11 | 8 | 13 | 40:39 | 1 | 41 |
| 7 |
|
Guayaquil SC | 32 | 12 | 4 | 16 | 34:45 | -11 | 40 |
| 8 |
|
Atlético Santo Domingo | 32 | 10 | 9 | 13 | 32:38 | -6 | 39 |
| 9 |
|
Liga de Portoviejo | 32 | 8 | 9 | 15 | 35:44 | -9 | 33 |
| 10 |
|
Atlético Porteño | 32 | 9 | 5 | 18 | 37:56 | -19 | 32 |
| Promotion | |
| Relegation |
