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| 1st(1st leg) | CSD Comunicaciones | - | Deportivo Marquense | 3:0 (1:0) | ||
| 2nd (2nd leg) | Deportivo Marquense | - | CSD Comunicaciones | 2:3 (0:1) | ||
| 1st(1st leg): 10/12/2010 02:00 | 2nd (2nd leg): 12/12/2010 19:00 | Winner: CSD Comunicaciones | ||||
| 1st(1st leg) | Deportivo Suchitepéquez | - | CSD Municipal | 2:3 (1:1) | ||
| 2nd (2nd leg) | CSD Municipal | - | Deportivo Suchitepéquez | 2:0 (1:0) | ||
| 1st(1st leg): 10/12/2010 02:00 | 2nd (2nd leg): 12/12/2010 17:00 | Winner: CSD Municipal | ||||
