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| 1st(1st leg) | Deportivo Mictlán | - | CSD Comunicaciones | 1:0 (1:0) | ||
| 2nd (2nd leg) | CSD Comunicaciones | - | Deportivo Mictlán | 3:0 (1:0) | ||
| 1st(1st leg): 01/12/2010 18:00 | 2nd (2nd leg): 05/12/2010 02:00 | Winner: CSD Comunicaciones | ||||
| 1st(1st leg) | Deportivo Suchitepéquez | - | Deportivo Heredia | 1:0 (1:0) | ||
| 2nd (2nd leg) | Deportivo Heredia | - | Deportivo Suchitepéquez | 3:3 (1:1) | ||
| 1st(1st leg): 02/12/2010 02:00 | 2nd (2nd leg): 05/12/2010 18:00 | Winner: Deportivo Suchitepéquez | ||||
