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| 1st(1st leg) | Antigua GFC | - | Comunicaciones | 0:0 (0:0) | ||
| 2nd (2nd leg) | Comunicaciones | - | Antigua GFC | 0:3 (0:2) | ||
| 1st(1st leg): 31/12/2020 16:00 | 2nd (2nd leg): 18/01/2021 00:00 | Winner: Antigua GFC | ||||
| 1st(1st leg) | Xelaju MC | - | Deportivo Malacateco | 1:0 (1:0) | ||
| 2nd (2nd leg) | Deportivo Malacateco | - | Xelaju MC | 0:2 (0:1) | ||
| 1st(1st leg): 31/12/2020 16:00 | 2nd (2nd leg): 03/01/2021 18:00 | Winner: Xelaju MC | ||||
| 1st(1st leg) | Deportivo Guastatoya | - | Cobán Imperial | 0:0 (0:0) | ||
| 2nd (2nd leg) | Cobán Imperial | - | Deportivo Guastatoya | 1:2 (0:0) | ||
| 1st(1st leg): 31/12/2020 17:00 | 2nd (2nd leg): 03/01/2021 18:00 | Winner: Deportivo Guastatoya | ||||
| 1st(1st leg) | Iztapa | - | CSD Municipal | 1:3 (0:1) | ||
| 2nd (2nd leg) | CSD Municipal | - | Iztapa | 3:1 (2:0) | ||
| 1st(1st leg): 31/12/2020 18:00 | 2nd (2nd leg): 03/01/2021 17:00 | Winner: CSD Municipal | ||||
