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| 1st(1st leg) | Deportivo Malacateco | - | Comunicaciones | 2:0 (1:0) | ||
| 2nd (2nd leg) | Comunicaciones | - | Deportivo Malacateco | 0:0 (0:0) | ||
| 1st(1st leg): 30/12/2021 17:00 | 2nd (2nd leg): 03/01/2022 02:00 | Winner: Deportivo Malacateco | ||||
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|
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| 1st(1st leg) | Deportivo Malacateco | - | Comunicaciones | 2:0 (1:0) | ||
| 2nd (2nd leg) | Comunicaciones | - | Deportivo Malacateco | 0:0 (0:0) | ||
| 1st(1st leg): 30/12/2021 17:00 | 2nd (2nd leg): 03/01/2022 02:00 | Winner: Deportivo Malacateco | ||||
