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| 1st(1st leg) | Vida | - | Motagua | 0:3 (0:0) | ||
| 2nd (2nd leg) | Motagua | - | Vida | 0:0 (0:0) | ||
| 1st(1st leg): 05/05/2022 02:30 | 2nd (2nd leg): 09/05/2022 00:00 | Winner: Motagua | ||||
| 1st(1st leg) | Marathón | - | Victoria | 4:1 (2:0) | ||
| 2nd (2nd leg) | Victoria | - | Marathón | 1:1 (0:0) | ||
| 1st(1st leg): 06/05/2022 02:06 | 2nd (2nd leg): 08/05/2022 02:00 | Winner: Marathón | ||||
