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| 1st(1st leg) | Victoria | - | Motagua | 0:0 (0:0) | ||
| 2nd (2nd leg) | Motagua | - | Victoria | 2:1 (1:0) | ||
| 1st(1st leg): 01/12/2022 01:30 | 2nd (2nd leg): 03/12/2022 22:30 | Winner: Motagua | ||||
| 1st(1st leg) | Marathón | - | Olimpia | 1:3 (1:1) | ||
| 2nd (2nd leg) | Olimpia | - | Marathón | 1:3 (1:2) | ||
| 1st(1st leg): 01/12/2022 21:05 | 2nd (2nd leg): 05/12/2022 00:00 | |||||
