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| 19/02/2021 | 11:00 | Nordia Jerusalem | - | FC Tira | 10:9 pso | |
| 11:00 | Maccabi Netanya | - | Hapoel Bik'at HaYarden | 2:0 | ||
| 12:00 | Hapoel Ramat Gan | - | Hapoel Bnei Lod | 4:1 aet | ||
| 12:00 | FC Kafr Qasim | - | Hapoel Kfar Saba | 0:2 | ||
| 12:00 | Hapoel Afula | - | Hapoel Nof HaGalil F.C | 5:3 pso | ||
| 12:00 | Hapoel Jerusalem | - | Hapoel Rishon LeZion | 1:0 aet | ||
| 12:00 | Sektzia Nes Tziona | - | Maccabi Petach-Tikva | 0:1 aet | ||
| 20/02/2021 | 15:15 | Bnei Yehuda Tel Aviv | - | Hapoel Haifa | 4:5 pso | |
| 18:30 | Maccabi Haifa | - | Hapoel Umm al-Fahm FC | 2:1 | ||
| 21/02/2021 | 17:30 | Beitar Tel Aviv Bat Yam | - | Ironi Kiryat Shmona | 2:0 | |
| 17:35 | Hapoel Kfar Shalem | - | Agudat Sport Ashdod | 3:1 | ||
| 18:00 | Hapoel Acre FC | - | Beitar Jerusalem | 0:2 | ||
| 18:45 | Hapoel Be'er Sheva | - | Maccabi Tel Aviv | 0:1 | ||
| 22/02/2021 | 17:45 | Bnei Sachnin FC | - | Hapoel Hadera FC | 3:0 | |
| 18:00 | FC Ashdod | - | Hapoel Ra'anana | 3:1 | ||
| 18:30 | Hapoel Tel Aviv | - | Hapoel Ashkelon | 4:0 |
