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| 30/10/2021 | 15:00 | Progrès Niedercorn | - | Swift Hesperange | 3:2 pso | |
| 15:30 | Victoria Rosport | - | Union Titus Pétange | 2:4 | ||
| 16:30 | Alisontia Steinsel | - | F91 Dudelange | 2:6 | ||
| 17:00 | Jeunesse Useldange | - | US Mondorf | 2:4 | ||
| 17:00 | Blo-Weiss Medernach | - | CS FOLA Esch | 0:2 | ||
| 17:00 | Marisca Mersch | - | RFCU Luxemburg | 0:6 | ||
| 31/10/2021 | 15:00 | UN Käerjéng | - | FC Wiltz 71 | 3:2 | |
| 15:00 | US Rumelange | - | FC Mondercange | 0:5 | ||
| 15:00 | US Esch | - | Jeunesse Esch | 1:0 pso | ||
| 15:00 | Jeunesse Canach | - | FC Atert Bissen | 2:1 | ||
| 15:00 | Yellow Boys Weiler | - | US Hostert | 1:0 | ||
| 15:00 | FC Kehlen | - | Etzella Ettelbruck | 0:4 | ||
| 15:00 | Rupensia Lusitanos Larochette | - | FC Differdange 03 | 0:4 | ||
| 15:00 | SC Bettembourg | - | FC Mamer 32 | 1:0 | ||
| 15:00 | FC Schifflange 95 | - | RM Hamm Benfica | 3:0 | ||
| 15:00 | UNA Strassen | - | FC Rodange 91 | 2:1 |
