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| 06/04/2022 | 19:00 | UNA Strassen | - | Union Titus Pétange | 0:1 | |
| 19:00 | US Mondorf | - | F91 Dudelange | 0:4 | ||
| 19:00 | US Esch | - | Progrès Niedercorn | 3:9 | ||
| 19:00 | SC Bettembourg | - | Etzella Ettelbruck | 2:4 | ||
| 19:00 | RFCU Luxemburg | - | FC Differdange 03 | 1:0 | ||
| 19:00 | FC Schifflange 95 | - | Jeunesse Canach | 4:2 pso | ||
| 19:00 | UN Käerjéng | - | Yellow Boys Weiler | 2:0 | ||
| 19:00 | FC Mondercange | - | CS FOLA Esch | 0:4 |
