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| 28/10/2022 | 19:00 | FC Mamer 32 | - | US Hostert | 2:5 | |
| 19:00 | Syra Mensdorf | - | Marisca Mersch | 0:2 | ||
| 29/10/2022 | 18:30 | FC Red-Black/Egalite 07 | - | Swift Hesperange | 1:5 | |
| 30/10/2022 | 13:30 | Daring Club Echternach | - | US Mondorf | 0:7 | |
| 14:00 | FC Mondercange | - | Victoria Rosport | 0:2 | ||
| 14:00 | Jeunesse Esch | - | FC Wiltz 71 | 0:1 | ||
| 14:00 | CeBra 01 | - | UNA Strassen | 1:6 (0:5) | ||
| 14:00 | Etzella Ettelbruck | - | Union Titus Pétange | 2:3 aet | ||
| 14:00 | SC Bettembourg | - | F91 Dudelange | 1:4 | ||
| 14:00 | US Feulen | - | Berdenia Berburg | 1:2 | ||
| 14:00 | CS Grevenmacher | - | FC Differdange 03 | 0:2 | ||
| 14:00 | FC Schengen | - | CS FOLA Esch | 1:3 (0:0, 1:1) aet | ||
| 14:00 | Blo-Weiss Medernach | - | FC Luxemburg City | 1:4 | ||
| 14:00 | Avenir Beggen | - | RFCU Luxemburg | 0:3 | ||
| 14:00 | US Rumelange | - | Jeunesse Schieren | 3:1 | ||
| 14:30 | Progrès Niedercorn | - | UN Käerjéng | 1:0 |
