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| 1st(1st leg) | Atlas Guadalajara | - | CF Monterrey | 0:0 (0:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | Atlas Guadalajara | 1:0 (1:0) | ||
| 1st(1st leg): 14/11/2019 21:45 | 2nd (2nd leg): 19/11/2019 01:00 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Club Tijuana | - | UANL Tigres | 0:0 (0:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | Club Tijuana | 3:0 (0:0) | ||
| 1st(1st leg): 15/11/2019 03:00 | 2nd (2nd leg): 18/11/2019 01:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Deportivo Toluca | - | CF Pachuca | 1:4 (1:2) | ||
| 2nd (2nd leg) | CF Pachuca | - | Deportivo Toluca | 1:2 (1:0) | ||
| 1st(1st leg): 15/11/2019 23:00 | 2nd (2nd leg): 19/11/2019 03:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Deportivo Guadalajara | - | CF América | 0:2 (0:2) | ||
| 2nd (2nd leg) | CF América | - | Deportivo Guadalajara | 1:0 (1:0) | ||
| 1st(1st leg): 16/11/2019 03:06 | 2nd (2nd leg): 18/11/2019 21:45 | Winner: CF América | ||||
