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| 26/03/2022 | 15:00 | CF Pachuca | - | Pumas UNAM | 2:2 (1:1) | |
| 17:30 | Santos Laguna | - | Mazatlán FC | 3:2 (3:1) | ||
| 17:30 | Club León | - | Deportivo Guadalajara | 1:4 (0:2) | ||
| 17:30 | Deportivo Toluca | - | Gallos Blancos | 3:0 (2:0) | ||
| 17:30 | Cruz Azul | - | FC Juárez | 0:2 (0:0) | ||
| 17:45 | Atlético San Luis | - | CF Monterrey | 0:3 (0:1) | ||
| 20:45 | Club Tijuana | - | UANL Tigres | 3:1 (2:1) | ||
| 22:00 | Puebla FC | - | Club Necaxa | 0:3 (0:2) |
| » Tables | Home | Away | First round | Second round |
| 1 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 11 | 8 | 1 | 2 | 33:13 | 20 | 25 |
| 2 |
|
Pumas UNAM | 11 | 7 | 4 | 0 | 24:12 | 12 | 25 |
| 3 |
|
Deportivo Toluca | 11 | 6 | 2 | 3 | 21:16 | 5 | 20 |
| 4 |
|
Club Necaxa | 10 | 5 | 2 | 3 | 24:14 | 10 | 17 |
| 5 |
|
FC Juárez | 10 | 5 | 1 | 4 | 13:12 | 1 | 16 |
| 6 |
|
Gallos Blancos | 11 | 4 | 2 | 5 | 10:17 | -7 | 14 |
| 7 |
|
CF América | 10 | 2 | 2 | 6 | 12:16 | -4 | 8 |
| 8 |
|
Cruz Azul | 11 | 2 | 1 | 8 | 14:27 | -13 | 7 |
| 9 |
|
Puebla FC | 11 | 1 | 1 | 9 | 5:29 | -24 | 4 |
| 2 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 11 | 8 | 3 | 0 | 25:6 | 19 | 27 |
| 2 |
|
UANL Tigres | 11 | 7 | 1 | 3 | 22:15 | 7 | 22 |
| 3 |
|
Santos Laguna | 11 | 6 | 3 | 2 | 21:16 | 5 | 21 |
| 4 |
|
Atlas Guadalajara | 10 | 6 | 2 | 2 | 27:13 | 14 | 20 |
| 5 |
|
CF Monterrey | 11 | 5 | 3 | 3 | 22:11 | 11 | 18 |
| 6 |
|
Club Tijuana | 10 | 5 | 1 | 4 | 19:15 | 4 | 16 |
| 7 |
|
Club León | 10 | 1 | 3 | 6 | 10:23 | -13 | 6 |
| 8 |
|
Atlético San Luis | 11 | 1 | 1 | 9 | 4:29 | -25 | 4 |
| 9 |
|
Mazatlán FC | 11 | 0 | 1 | 10 | 9:31 | -22 | 1 |
| Playoffs | |
| Playoffs |
