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| 23/03/2022 | 16:30 | Cruz Azul | - | Pumas UNAM | 1:4 (0:2) | |
| 30/03/2022 | 17:00 | Deportivo Guadalajara | - | CF Monterrey | 4:1 (2:1) | |
| 16/04/2022 | 17:30 | Atlas Guadalajara | - | Mazatlán FC | 5:1 (2:0) | |
| 17:30 | Gallos Blancos | - | Club Necaxa | 2:3 (2:1) | ||
| 18:30 | FC Juárez | - | Puebla FC | 4:0 (1:0) | ||
| 20/04/2022 | 20:45 | Club Tijuana | - | Santos Laguna | 4:1 (2:0) | |
| 03/05/2022 | 17:45 | Atlético San Luis | - | Club León | 0:3 (0:1) | |
| 04/05/2022 | 22:00 | Deportivo Toluca | - | CF América | 0:2 (0:0) |
| » Tables | Home | Away | First round | Second round |
| 1 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 13 | 9 | 4 | 0 | 30:14 | 16 | 31 |
| 2 |
|
CF Pachuca | 13 | 9 | 1 | 3 | 37:15 | 22 | 28 |
| 3 |
|
Club Necaxa | 13 | 7 | 2 | 4 | 29:18 | 11 | 23 |
| 4 |
|
Deportivo Toluca | 14 | 6 | 4 | 4 | 24:21 | 3 | 22 |
| 5 |
|
FC Juárez | 13 | 6 | 2 | 5 | 20:18 | 2 | 20 |
| 6 |
|
CF América | 13 | 5 | 2 | 6 | 22:18 | 4 | 17 |
| 7 |
|
Gallos Blancos | 14 | 4 | 2 | 8 | 13:25 | -12 | 14 |
| 8 |
|
Cruz Azul | 14 | 2 | 2 | 10 | 17:38 | -21 | 8 |
| 9 |
|
Puebla FC | 13 | 2 | 1 | 10 | 8:33 | -25 | 7 |
| 2 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 13 | 10 | 3 | 0 | 31:8 | 23 | 33 |
| 2 |
|
UANL Tigres | 13 | 9 | 1 | 3 | 28:17 | 11 | 28 |
| 3 |
|
Atlas Guadalajara | 13 | 8 | 2 | 3 | 33:15 | 18 | 26 |
| 4 |
|
Club Tijuana | 13 | 7 | 1 | 5 | 26:17 | 9 | 22 |
| 5 |
|
CF Monterrey | 14 | 6 | 3 | 5 | 27:19 | 8 | 21 |
| 6 |
|
Santos Laguna | 13 | 6 | 3 | 4 | 22:22 | 0 | 21 |
| 7 |
|
Club León | 13 | 4 | 3 | 6 | 17:23 | -6 | 15 |
| 8 |
|
Atlético San Luis | 14 | 1 | 1 | 12 | 4:37 | -33 | 4 |
| 9 |
|
Mazatlán FC | 14 | 0 | 1 | 13 | 11:41 | -30 | 1 |
| Playoffs | |
| Playoffs |
