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| 1st(1st leg) | Dorados de Sinaloa | - | Club Irapuato | 0:0 (0:0) | ||
| 2nd (2nd leg) | Club Irapuato | - | Dorados de Sinaloa | 1:1 (0:1) | ||
| 1st(1st leg): 28/04/2011 03:00 | 2nd (2nd leg): 01/05/2011 02:00 | Winner: Dorados de Sinaloa | ||||
| 1st(1st leg) | Cruz Azul Hidalgo | - | Club Tijuana | 2:2 (0:1) | ||
| 2nd (2nd leg) | Club Tijuana | - | Cruz Azul Hidalgo | 5:1 (4:0) | ||
| 1st(1st leg): 28/04/2011 22:00 | 2nd (2nd leg): 01/05/2011 21:00 | Winner: Club Tijuana | ||||
| 1st(1st leg) | Correcaminos UAT | - | Atlante UTN | 1:1 (0:0) | ||
| 2nd (2nd leg) | Atlante UTN | - | Correcaminos UAT | 1:0 (1:0) | ||
| 1st(1st leg): 29/04/2011 02:30 | 2nd (2nd leg): 01/05/2011 18:00 | Winner: Atlante UTN | ||||
