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| 1st(1st leg) | Leones Negros | - | Atlante | 1:1 (0:1) | ||
| 2nd (2nd leg) | Atlante | - | Leones Negros | 1:0 (0:0) | ||
| 1st(1st leg): 03/11/2022 01:00 | 2nd (2nd leg): 06/11/2022 01:00 | Winner: Atlante | ||||
| 1st(1st leg) | Cimarrones de Sonora | - | Club Celaya | 0:0 (0:0) | ||
| 2nd (2nd leg) | Club Celaya | - | Cimarrones de Sonora | 3:1 (1:0) | ||
| 1st(1st leg): 03/11/2022 02:10 | 2nd (2nd leg): 05/11/2022 21:00 | Winner: Club Celaya | ||||
