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| 26/03/2022 | 01:00 | Tecos Fútbol Club | - | Catedráticos Elite | 1:1 (1:0) | |
| 02:30 | Coras de Nayarit | - | Cimarrones de Sonora II | 2:1 (1:1) | ||
| 17:00 | Leones Negros II | - | Saltillo FC | 2:1 (2:1) | ||
| 21:30 | Tuzos de la UAZ | - | Correcaminos UAT II | 4:1 (4:1) | ||
| 21:30 | Mazorqueros | - | Gavilanes de Matamoros | 0:0 (0:0) | ||
| 22:30 | Colima FC | - | Tritones Vallarta | 0:2 (0:1) | ||
| 23:00 | Mineros de Fresnillo FC | - | Alacranes de Durango | 2:3 (0:2) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Tritones Vallarta | 11 | 8 | 2 | 1 | 22:9 | 13 | 31 |
| 2 |
|
Mazorqueros | 11 | 8 | 3 | 0 | 23:7 | 16 | 30 |
| 3 |
|
Alacranes de Durango | 11 | 6 | 4 | 1 | 27:10 | 17 | 25 |
| 4 |
|
Coras de Nayarit | 11 | 6 | 4 | 1 | 18:10 | 8 | 23 |
| 5 |
|
Saltillo FC | 11 | 6 | 1 | 4 | 17:17 | 0 | 20 |
| 6 |
|
Gavilanes de Matamoros | 11 | 3 | 6 | 2 | 13:8 | 5 | 17 |
| 7 |
|
Tuzos de la UAZ | 11 | 3 | 5 | 3 | 20:16 | 4 | 16 |
| 8 |
|
Cimarrones de Sonora II | 11 | 4 | 2 | 5 | 14:12 | 2 | 16 |
| 9 |
|
Tecos Fútbol Club | 11 | 3 | 4 | 4 | 10:16 | -6 | 15 |
| 10 |
|
Mineros de Fresnillo FC | 11 | 1 | 5 | 5 | 15:22 | -7 | 10 |
| 11 |
|
Leones Negros II | 11 | 2 | 3 | 6 | 11:21 | -10 | 9 |
| 12 |
|
Colima FC | 11 | 2 | 2 | 7 | 8:18 | -10 | 9 |
| 13 |
|
Correcaminos UAT II | 11 | 2 | 2 | 7 | 9:20 | -11 | 9 |
| 14 |
|
Catedráticos Elite | 11 | 0 | 3 | 8 | 6:27 | -21 | 3 |
| Playoffs |
