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| 1st(1st leg) | Chihuahua FC | - | Tampico Madero | 0:0 (0:0) | ||
| 2nd (2nd leg) | Tampico Madero | - | Chihuahua FC | 3:2 (1:1) | ||
| 1st(1st leg): 03/11/2022 02:00 | 2nd (2nd leg): 05/11/2022 21:30 | Winner: Tampico Madero | ||||
| 1st(1st leg) | Cafetaleros de Chiapas | - | Tuzos de la UAZ | 1:2 (1:0) | ||
| 2nd (2nd leg) | Tuzos de la UAZ | - | Cafetaleros de Chiapas | 5:2 (4:0) | ||
| 1st(1st leg): 03/11/2022 02:00 | 2nd (2nd leg): 05/11/2022 21:30 | Winner: Tuzos de la UAZ | ||||
