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| 1st(1st leg) | CD Ayense | - | Santiago FC | 0:2 (0:1) | ||
| 2nd (2nd leg) | Santiago FC | - | CD Ayense | 2:0 (2:0) | ||
| 1st(1st leg): 24/04/2025 02:00 | 2nd (2nd leg): 27/04/2025 01:00 | Winner: Santiago FC | ||||
| 1st(1st leg) | Artesanos Metepec | - | Atlético Pachuca | 1:1 (0:1) | ||
| 2nd (2nd leg) | Atlético Pachuca | - | Artesanos Metepec | 1:1 (1:1) | ||
| 1st(1st leg): 24/04/2025 23:00 | 2nd (2nd leg): 27/04/2025 23:00 | |||||
